Sequence variation in a newly identified HLA-B35-restricted epitope in the influenza A virus nucleoprotein associated with escape from cytotoxic T lymphocytes.

نویسندگان

  • A C M Boon
  • G de Mutsert
  • Y M F Graus
  • R A M Fouchier
  • K Sintnicolaas
  • A D M E Osterhaus
  • G F Rimmelzwaan
چکیده

Here, we describe a new HLA-B*3501-restricted cytotoxic T lymphocyte (CTL) epitope in the influenza A virus (H3N2) nucleoprotein, which was found to exhibit a high degree of variation at nonanchor residues. The influenza virus variants emerged in chronological order, and CTLs directed against old variants failed to recognize more recent strains of influenza A virus, indicating an escape from CTL immunity.

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عنوان ژورنال:
  • Journal of virology

دوره 76 5  شماره 

صفحات  -

تاریخ انتشار 2002